Endometriosis
Highly prevalent chronic inflammation.
Studied, Designed and Supported by teams from
Studied, Designed and Supported by teams from
Nettle™ - Medical Wearable for Menstrual Pain and Mood Relief
Drug and hormone-free pain and mood relief across the menstrual cycle. Nettle™ delivers gentle non-invasive neurostimulation, keeping your brain in balance even during hormonal changes.
Device Plan
Choose how you'd like to get your device
App Membership
1
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See what our users are saying
Why the brain
89% of our users report using fewer medications
All statistics taken from the Six Month Nettle User Survey (2025)
80%
of users report "fewer sick days or interruptions to daily life"*
4.7
fewer GP or specialist visits reported on average per user per year
25%
of all users reduced their use of hormonal treatments.
Why the brain
Clinically tested for real-life support.
Nettle™ uses neuroscience, clinically tested technology and thoughtful design to create tools that help you feel more in control - improving focus, easing burnout, supporting mood and reducing brain fog.
It’s all in your brain.
Mood, pain, motivation - they start and end in the brain.
It’s not random. It’s a rhythm.
Even if its complex or irregular, your cycle has a pattern you can work with, not just endure.
Clinically tested real-life support.
Nettle™ neuroscience and smart design to help you feel clearer, steadier, and in control.
Simple, effective and safe.
How to use Nettle™
Designed from the ground up to be easy to use with no severe side effects, Nettle™ easily integrates into your life - no matter what your day looks like.
Step01
Schedule
Get notified when you need it
Step02
Setup
Be ready to go in under two minutes
Step03
Integrate
Use Nettle™ during other activities
Step04
Monitor
See your progress
Brain, body, mind – all working together.
Decades of research show that the brain can rewire itself - with the right kind of stimulation. Pair Nettle™’s cutting edge science with holistic care in the Samphire app. Working with your cycle, not against it, you build a foundation for relief.
Mood Swings
Nettle™ rebalances activity in the brain’s prefrontal cortex, helping calm fight-or-flight responses.
Integrated care
Nettle™ integrates with Samphire, giving you personalised guidance across your entire cycle.
Pain Relief
Nettle™ retrains the brain’s response to pain by modulating overactive pathways - teaching your system to react differently.
Cycle resilience
Each time you use Nettle™, you’re creating adaptive brain responses to boost your overall reslience.
Mood Swings
Nettle™ rebalances activity in the brain’s prefrontal cortex, helping calm fight-or-flight responses.
Integrated care
Nettle™ integrates with Samphire, giving you personalised guidance across your entire cycle.
Pain Relief
Nettle™ retrains the brain’s response to pain by modulating overactive pathways - teaching your system to react differently.
Cycle resilience
Each time you use Nettle™, you’re creating adaptive brain responses to boost your overall reslience.
94% of users feel better in just three months.*
We invest in rigorous science, conducting randomized, placebo-controlled, double-blind clinical trials to ensure the safety and effectiveness of Nettle's™ technology.
97%
of users find Nettle™ easy to integrate into their lives.
67%
noticed mood improvements within one cycle.
72%
experienced reduced pain within one cycle.
93%
felt relief within three cycles of personalized use.
What we help with
Explore our perspectives on women’s health below.
Too often, systems treat symptoms in isolation. Samphire’s solutions work across the brain, body and cycle - connecting the dots between pain, mood, focus, hormones and more.
Premenstrual Syndrome
Widespread but often overlooked mood and body shifts.
ADHD and Neurodiversity
Differences in focus and attention.
Neuroplasticity
The brain's ability to reorganize and adapt through experience.
Premenstrual Dysphoric Disorder
Severe PMS symptoms causing mood changes and physical discomfort.
Dysmenorrhea
Painful menstrual cramps that can disrupt daily activities.
Sleep and Rest
Supporting quality sleep to restore energy and balance.
Emotions and Mood Swings
Managing sudden mood shifts and emotional sensitivity.
Stress and Anxiety
Reducing tension and calming the mind during the cycle.
Backed by science, proven by you.
These are the experiences of people using our solutions every day.
Then in the third month, my PMS symptoms were reduced by 80%! I still have menstrual pain, but the intensity has decreased again a bit.
Moko
I'm four cycles in... and will never look back. The changes were gradual and cumulative, but by the third cycle I felt as though my life had completely changed, I haven't had to take a day off work due to PMDD symptoms since the second cycle of using Nettle.
Emma
I really love this company. It is weird to say I feel seen and cared for by them. I just don't think I have felt like this with any other business.
Rachel
Has been life-changing for me. It has significantly improved my mental health, not just during the intense phases of PMDD before my period. But I actually feel much better during the rest of my cycle, too.
Jasmin
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