Question 1

What are Nettle™ and Lutea™ and what do they do?

Accepted Answer

Nettle™ and Lutea™ are wearable devices that stimulate the same regions of the brain associated with pain and mood. Nettle™ is a CE-certified medical device available only in the UK and EU, clinically validated for managing mood and pain symptoms associated with menstruation. Lutea™ is a daily wellness device designed to support balance, calm, and focus throughout the menstrual cycle. It’s a consumer wellness product available without prescription in the US, Canada, and select other countries. Both pair with the Samphire App, offering neuroscience-based tracking of your experience across your cycle. To understand more about neurostimulation, visit this article in our support centre.

Question 2

How do I use my device?

Accepted Answer

For best results, use your device once a day for 20 minutes over three consecutive menstrual cycles. Most users only need it on about five days per cycle, starting before symptoms begin - this helps prevent pain and mood changes before they appear. You may start to feel benefits sooner, but we recommend completing three full cycles for the most true results, as everyone’s body (and brain!) respond differently. To ensure the correct fit and placement, follow the user manual or watch the instructional videos in the Samphire app.

Question 3

What does it feel like?

Accepted Answer

Some users describe a mild tingling sensation where the device rests - that’s a normal effect of the gentle electrical current and usually fades within a few minutes. This sensation also declines with use. Whether you feel it or not does not affect how well it works.

Question 4

How quickly will I see results?

Accepted Answer

Some users may start to feel benefits within the first few weeks of use. However, for optimal results, we recommend using your device consistently for at least 3 consecutive menstrual cycles.

Question 5

Can I share my device with others?

Accepted Answer

Yes - you can share your device as long as each person has their own Samphire subscription for accurate tracking. For full details on sharing, subscriptions, and best practices, visit our Support Centre.

Question 6

Can I use HSA/FSA funds to purchase my device and a Samphire subscription?

Accepted Answer

Yes - American customers can use their HSA or FSA funds to purchase Lutea™ and a Samphire app subscription. If you have an HSA or FSA debit card, you can select it as your payment method at checkout. Eligibility is confirmed during checkout in line with HSA/FSA guidelines. For more information, visit this article in our blog.

Question 7

Is neurostimulation safe?

Accepted Answer

Yes - neurostimulation is a safe, non-invasive, and non-hormonal technology that has been used for over 30 years in clinical and research settings - to modulate brain activity involved in pain and mood regulation.  There has never been a serious adverse event (side effect) reported in relation to the use of this technology. If you'd like to delve deeper into the scientific consensus report on the technology's safety, it is available here.

Question 8

Who shouldn’t use neurostimulation?

Accepted Answer

You should not use neurostimulation if you are: Under 18 years old Pregnant or may be pregnant Have epilepsy or a history of seizures Have neurological implants (like cochlear implants or deep-brain stimulators) Have active suicidal thoughts or severe psychiatric illness Have cranial lesions, tumours, or other defects in the skull If you have any medical concerns, please review this support article and consult your healthcare provider before using neurostimulation.

Question 9

Can I use neurostimulation during my period?

Accepted Answer

Yes, you can use neurostimulation during your period. In fact, many users find it particularly helpful for managing menstrual pain (dysmenorrhea) and discomfort during this time.

Question 10

Can I use neurostimulation if I am pregnant or breastfeeding?

Accepted Answer

Neurostimulation should not be used during pregnancy. However, there’s no cause for concern if you used neurostimulation before realizing you were pregnant. The device is designed for use during menstrual cycles, which naturally stop in pregnancy. The contraindication simply reflects that neurostimulation isn’t needed or studied for use in pregnancy, not that it poses a known risk. If you are pregnant, we recommend pausing use and consulting your healthcare provider before resuming.

Question 11

What menstrual conditions can neurostimulation treat?

Accepted Answer

Because neurostimulation targets the brain pathways involved in pain and emotional regulation, many users find it helpful for PMS, PMDD, and painful periods, even when symptoms overlap between conditions. Our Nettle™ device is approved for use in primary dysmenorrhea (period pain), premenstrual syndrome (PMS) and is also being investigated for use in Premenstrual Dysphoric Disorder (PMDD) and endometriosis-related chronic pelvic pain through ongoing clinical research.

Question 12

Can neurostimulation help with endometriosis symptoms?

Accepted Answer

Neurostimulation is not approved as a medical treatment for endometriosis. However, our Nettle™ device is currently being piloted with the NHS in London for endometriosis-related chronic pelvic pain and many current users report benefits. Many users with endometriosis report that neurostimulation helps them manage cramps, fatigue, and mood symptoms more comfortably throughout their cycle.

Question 13

Is neurostimulation effective for PMDD symptoms?

Accepted Answer

Neurostimulation is designed to help with both the pain and mood symptoms associated with menstruation. In our clinical studies, 44% of participants had Premenstrual Dysphoric Disorder (PMDD), and many current users report that neurostimulation helps them manage mood changes, cramps, and overall wellbeing throughout their cycle. We're also collaborating with Queen Mary University of London to further study neurostimulation's potential in PMDD.

Question 14

Can neurostimulation be used with other medical treatments?

Accepted Answer

Yes. Neurostimulation can be safely used alongside medications, including antidepressants and hormonal contraception. It should not be used at the same time as another active neurostimulation device. Before using any neurostimulation product, you should carefully review the user manual, and if in doubt, consult with your healthcare professional.

Question 15

What clinical evidence supports your products?

Accepted Answer

Our products are backed by extensive research, including: Published peer-reviewed studies demonstrating the efficacy of neurostimulation for symptom relief Clinical trials conducted in partnership with leading universities Real-world data from thousands of users tracking their symptoms You can learn more about the science behind our approach on our science page.

Question 16

Who are your research partners?

Accepted Answer

We collaborate with world-leading research institutions including: University College London (UCL) Imperial College London Harvard Medical School Federal University of Rio Grande do Norte (UFRN) These partnerships ensure our products are developed using the latest scientific insights and rigorous methodology.

Question 17

What does the research say about neurostimulation?

Accepted Answer

Neurostimulation has been studied for over three decades, with thousands of published papers examining its effects on various conditions. Research has shown neurostimulation can modulate brain activity and neuroplasticity, with benefits for: Pain management Mood regulation Cognitive function Our specific protocols have been optimized based on this body of research and our own clinical trials. If you want to learn more about neurostimulation, visit our science page.

Question 18

Are Nettle™ and Lutea™ medical devices?

Accepted Answer

Nettle™ is a CE-certified medical device available only in the UK and EU, clinically validated for managing mood and pain symptoms associated with menstruation. Lutea™ is a consumer wellness device designed to support balance, calm, and focus throughout the menstrual cycle. It is available without prescription in the US, Canada, and select other countries. Both Nettle™ and Lutea™ have undergone rigorous testing and quality assurance processes to ensure they are safe and effective for their intended use.

Question 19

Are there any upcoming clinical trials I can join?

Accepted Answer

Yes, we're actively running studies for PMDD, endometriosis, and chronic pelvic pain with NHS, UCLH, and international partners. Sign up to our newsletter or follow us on Instagram for recruitment announcements. You can see a list of current trials on our website here.

Question 20

How long does shipping take?

Accepted Answer

Standard shipping typically takes 3-5 business days within the UK. International shipping times vary by destination: UK: 2-4 business days EU countries: 5-7 business days US: 2-3 business days Rest of world: 10-14 business days For more details about delivery to your location, see our shipping information page.

Question 21

Do you ship internationally?

Accepted Answer

We ship Nettle™ to the UK and EU, where it is approved as a medical device. We ship Lutea™ to the US and selected international countries. Lutea™ is a wellness device and is not classified as a medical device. If you don't see your country listed at checkout, please contact support@samphireneuro.com and we'll be happy to help.

Question 22

How much does shipping cost?

Accepted Answer

We offer free standard shipping on orders to the UK, EU and the USA. Other international shipping costs are calculated at checkout based on your delivery address. Wherever possible, we offer express shipping as an option at checkout.

Question 23

How do I track my order?

Accepted Answer

Once your order has been dispatched, you'll receive an email with your tracking number and a link to track your delivery. You can also track your order by logging into your account. If you haven't received a tracking email within 48 hours of placing your order, please check your spam folder or contact our support team.

Question 24

What is your returns policy?

Accepted Answer

Our returns policy depends on the device you purchase: Nettle™: Comes with a 90-day money-back guarantee, giving you enough time to try Nettle™ for up to three menstrual cycles. Lutea™: Comes with a 30-day money-back guarantee from the date of delivery. If you're not completely satisfied with your purchase, you can request a return within the applicable guarantee period and receive a full refund - subject to eligibility requirements. Read the full Returns Policy for details on eligibility, exclusions, and how to start a return. To initiate a return contact our support team Please note that items must be in their original condition and packaging.

Question 25

Can I return items even if I live overseas?

Accepted Answer

Yes, international customers can return items, though return shipping costs may apply depending on your location. Please contact our support team to arrange a return.

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