A brain-first framework for perimenopause management: the case for non-invasive neuromodulation
Radyte, E. (et al) • 6 July 2026
Hormones don’t change how you feel. That’s your brain’s job.
Samphire targets the brain’s response to hormonal change — where pain, mood, and focus are actually generated.
The Science Behind Samphire
Symptom Analysis
Are your symptoms linked to hormones? Are they severe? How do they manifest? We’ll help build a structured picture of your situation.
Mood dominant
Worse in luteal phase
High severity
CycleSync™
Building your protocol…
Setup your schedule
Our clinical research team will set up a personalized schedule for you, using our CycleSync™ AI algorithm.
Meet your Care Advisor
You’ll be paired with an experienced advisor, who can guide you through the process and any questions.
Start stimulating
You’ll be in control, with twenty minute neurostimulation sessions running 5–20 days a month.
Get to actually live your life
As life changes, your protocol will change with you. Your Headband will be with you every step of the way.
The
Samphire Headband
Samphire has developed a proprietary neurotechnology device that uses transcranial direct current stimulation (tDCS) to stimulate critical brain regions associated with mood (prefrontal cortex) and pain (motor cortex via the posteria insula).
It is the only clinical grade, approved treatment for managing chronic pain and mood symptoms associated with hormonal change, currently expanding into a wide range of other indications.
Precisely targetskey brain regions
The MotorCortexThe Motor Cortex
Dysregulation canaffect pain sensitivityand physical tension.Dysregulation can affect painsensitivity and physical tension.
The PrefrontalCortexThe Prefrontal Cortex
Dysregulation canaffect mood, focusand emotional control.Dysregulation can affect mood,focus and emotional control.
Clinically testedacross a range of endpoints
0.0%
of people achieved an over 30% reduction in their anxiety symptoms.
GAD-7 assessment. Twice as effective as placebo. From the ADAPT trial (2026, in peer review, conducted by Prof Paul Faulkner from QMUL) on women with PMDD (who were not on any other intervention other than the Samphire Headband).
Headband and Guided Care
Samphire is available in your destination once we confirm it’s right for you. Take our quick eligibility assessment to get started.
What's included
Proprietary
clinical research
ENHANCE
United Kingdom · In progress
Evaluating Samphire for
endometriosis-related chronic pelvic pain.
Working
with
ADAPT
United Kingdom · Completed
Evaluating Samphire for
premenstrual dysphoric disorder (PMDD).
Working
with
RELIEF
United States · In progress
Evaluating Samphire for
endometriosis-related chronic pelvic pain.
Working
with
HOPE
Brazil · In progress
Evaluating Samphire for
pain, fatigue and quality of life among endometriosis patients.
Working
with
HOLD
Brazil · Completed
Evaluating Samphire for
pain and mood associated with menstruation.
Working
with
CREST
United States · In progress
Evaluating Samphire for
productivity, everyday function and quality of life.
Working
with
PAUSE
Lithuania · Planned
Evaluating Samphire for
cognition and brain fog in menopause and perimenopause.
Working
with
Our conference presentations & publications
Poster abstractInternational Neuromodulation Society Annual Meeting
Cycle-timed design considerations for decentralised neuromodulation trials in women's health
Samphire Neuroscience • 11–14 May 2026
Poster abstractInternational Society for Exercise Neuroscience
Don't Stop Moving: Wearable tDCS as a Neural Bridge for Menstrual Cycle-Related Exercise Drop-Off
Samphire Neuroscience • 18–19 July 2026
Poster abstractInternational Association for the Study of Pain
Home-Based Brain Stimulation for Endometriosis-Related Chronic Pelvic Pain: Trial in Progress
Samphire Neuroscience • 26–30 October 2026
Poster abstractMenstruation Research Conference
Interrupting the cycle: at-home neuromodulation as an upstream strategy for premenstrual low mood
Samphire Neuroscience • 7–8 July 2026
