Launching Lutea™ - and how it's different to Nettle™

When we launched Samphire, our goal was clear: to bring neuroscience into women’s hands for the first time, starting with understanding - and then managing - menstrual wellbeing.

In 2023, we launched the Samphire App globally, the most comprehensive digital ecosystem for tracking and understanding your cycle. It allows you to track symptoms that define your experience, understand trends related to your menstrual experience that can’t be picked up with physiological measures alone, track overlapping conditions, medications and improve your overall awareness of hormone-related wellbeing from a brain perspective: be that around periods, pregnancy or perimenopause and menopause.

In 2024, in the EU & UK we launched Nettle™ - the first and only medical-grade wearable treatment for PMS and menstrual pain. Over the past year, Nettle™ has reached thousands of women across the UK and EU, helping them navigate symptoms associated with conditions like PMS, PMDD, PCOS and endometriosis with a completely new, brain-based approach.

Now, we’re thrilled to introduce Lutea™ - our newest product, and our first release in the United States. Lutea™ is built on the same scientific foundation as Nettle™, but it represents a new perspective on how we think about women’s brain health, daily wellbeing, and self-care.

From medical to every day - because being a woman is a daily exercise

Nettle™ is a CE-certified Class IIa medical device, backed by clinical evidence - including data from the WIND trial and ongoing NHS and university-led studies. It was designed specifically to reduce pain and mood symptoms linked to menstrual cycles and conditions like endometriosis and PMDD. Nettle™ is only available for sale within the United Kingdom and the European Union.

Lutea™, by contrast, is a wellness device - registered for consumer use and designed for the U.S. and global wellness market. While it’s powered by the same neuromodulation principles as Nettle™, it’s positioned differently: not as a treatment, but as a daily tool for calm, focus, and clarity during hormonally sensitive moments. Lutea™ is now available for pre-orders in the United States, Canada and select global markets (while supplies last).

You can think of Nettle™ as a therapy - and Lutea™ as an everyday companion to your everyday balance around hormonal uncertainty.

What makes Lutea™ different

While both devices use gentle, non-invasive brain stimulation to support the brain regions involved in mood and stress regulation, their intended uses and claims differ.

Nettle™ is a medical device that’s undergone rigorous clinical testing and is used for managing pain and mood symptoms associated with the menstrual cycle.

Lutea™, on the other hand, is a science-informed wellness product designed to help users feel more grounded, focused, and balanced — without making any medical or treatment claims.

Both devices are controlled by the Samphire App, with user experience differing based on the product used.

Lutea™ draws on more than three decades of published research into transcranial direct current stimulation (tDCS) - a well-established, non-invasive form of brain stimulation studied for its ability to safely and gently modulate brain activity. This body of evidence informs how Lutea™ is designed, while its purpose remains firmly within the domain of everyday wellbeing and self-care.

Who each product is for

If you’re experiencing moderate to severe cyclical pain or mood changes, and you live in the UK or EU, Nettle™ is the best fit for you - it’s a CE-certified, clinically validated medical device available both directly on our website and through certified clinicians in your area.

If you’re based in the US, or you’re looking for a daily brain-care routine that supports calm and focus during hormonally sensitive moments, Lutea™ is designed for you. It’s available on our website, with no prescription required. Pre-orders (at -30%!) are open while supplies last, and all orders placed prior to Dec 1 will be delivered by Dec 23, 2025.

Why both matter

At Samphire, we’ve always believed that women deserve more than one-size-fits-all solutions. Our brains and bodies are dynamic, and our tools for wellbeing should reflect that.

By offering both Nettle™ and Lutea™, we’re creating a continuum of support:

• Clinical-grade technology for those managing chronic, cyclical conditions, and
• Everyday neuro-wellness tools for those seeking balance, focus, and calm through their hormonal cycles.

All of our products are rooted in neuroscience. All our products are built to empower women to understand and support their brains - which regulate their hormones.

Lutea™ is now available for pre-orders in the United States, order here.