"What if there was a drug-free and effective way to manage both menstrual pain and mood disorders?"
Smart relief. Better days.
Drug and hormone free relief for period pain and mood symptoms
Feel better
every day of every cycle.
Nettle™
United KingdomEuropean Union
Discover Nettle™ 
Clinically proven to relieve menstrual pain and low mood
Class lla medical device, approved in UK and Europe
Feel better from home - just 20 minutes a day, a few days each cycle.
Samphire
Global availability
$6.99 / month
$69.99 / year
Personalized symptom tracking and insights across your cycle
Breathwork and meditation tailored to your cycle phase
Smart cycle predictions to help you plan ahead
Lutea™
United StatesCanada+47 countries
Buy from $589.00
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Maximize wellbeing throughout the cycle, based on Nettle™'s technology
FCC registered and 60601 tested wellness device
Feel better from home - just 20 minutes a day, a few days each cycle.
Why the brain
Neuroplasticity holds the key
Your brain is the connection between your hormones and how you feel. We use both active and passive strategies to balance brain activity across your cycle - leading to fewer up and downs, and more stable, sustainable menstrual cycles.
How hormones affect your brain across your cycle
We study PMS, PMDD, endometriosis, focus, mood and more
Personalized support through integrated wearables and software
Evidence
94% of our users feel better in just three months.*
“I waited for my bleak day... the one I usually spend holding back tears... It didn’t come.”
“Samphire Neuroscience is redefining women’s health with brain-based wearables”
* Based on our clinically validated, double-blind study on Nettle™ (WIND 2024)
Balance
starts in the brain
Our award-winning solutions are designed to boost and balance your brain health across the cycle. It’s menstrual care that starts where your cycle really begins.
All natural, drug and hormone-free
Clinically tested, studied and validated
Holistic pairing of modern and ancient techniques
Smart cycle predictions to help you plan ahead
Feel better from home - just 20 minutes a day, a few days each cycle.
What we help with
Explore our perspectives on women’s health below.
Too often, systems treat symptoms in isolation. Samphire’s solutions work across the brain, body and cycle - connecting the dots between pain, mood, focus, hormones and more.
Shan N.
Most incredible decision I have made to…
02 Dec 2025
Most incredible decision I have made to support my health. My pain is much more manageable, my quality of life has improved drastically. Also, the customer support is out of this world. I recommend this to everyone I believe it could be useful for. Incredible 100/10!
Amy Bloemendaal
Using a Nettle has changed my life
13 Nov 2025
This headband is an absolute game changer!! I am literally recommending it to any woman, who deals with an overwhelming luteal phase. Thank you so much Samphire Neuroscience, everyone I have been in contact with has been so helpful and kind.
Marie
Great product
12 Nov 2025
This is truly one of the most honest and amazing companies out there. Their customer service goes above and beyond every time. You can really feel that they operate with integrity and strong ethics. Also — the headband works amazing!
Emma
PMDD / Perimenopause game changer
21 May 2025
This device has helped me to feel like myself again, my symptoms are so much less severe than they used to be! I have been diagnosed with PMDD as a result of early perimenopause - the mood related symptoms were overwhelming, and I would often need to miss at least one day of work each cycle as a result.
Rachel Young
This has been an actual gamechanger for my pmdd
8 Aug 2025
I have had a wonderful three months so far. The Nettle headband has helped with my cramps and my PMDD extreme emotions. The app that you use along with it has meditation for each phase of your period. It also let's you log all of your emotions, over or under eating, really anything that you associate with your menstrual cycle. The longer you use it and the more often you log things the more info it has to show you how you are really feeling and doing. You can compare the changes over the months easily. The people that work at the company and I think the founder are so responsive and helpful with every question and issue that I have had. I really love this company. It is weird to say I feel seen and cared for by them. I just don't think I have felt like this with any other business.
Jasmin
Nettle has been life-changing for me
6 Apr 2025
Nettle has been life-changing for me. It has significantly improved my mental health, not just during the intense phases of PMDD before my period. But I actually feel much better during the rest of my cycle, too. The improvement of my pain has been slower and has little effect in my case so far, but I don't mind that, considering how well it works for my mood. Samphire has been truly brilliant in supporting me with questions I've had and also have been very generous when it came to technical issues. The founder Emilie is very accessible, and makes time for you. I am routing for Samphire Nettle and hope that many women will benefit from it - I certainly tell everyone about it.
Blog
Our latest research
Our science and technology teams write extensively on why the brain matters in women’s health.
