HSA / FSA Eligible
Science

Research background

A curated selection of peer-reviewed research that informs our scientific approach — including Samphire's own publications and conference presentations alongside key external studies referenced across our science pages.

Endometriosis & Chronic Pelvic Pain

3 papers
Samphire research
Poster abstract

Home-Based Brain Stimulation for Endometriosis-Related Chronic Pelvic Pain: Trial in Progress

Samphire Neuroscience • International Association for the Study of Pain • 26–30 October 2026

Investigating the efficacy of transcranial direct current stimulation on chronic pain management in endometriosis patients: A randomized controlled trial protocol

da Silva, T. (et al). • 2024

Transcranial direct current stimulation to reduce chronic pelvic pain in endometriosis: Phase II Randomized Controlled Clinical Trial

Mechsner, S. (et al) • 2023

Menstrual Cycle & Exercise

2 papers
Samphire research
Poster abstract

Don't Stop Moving: Wearable tDCS as a Neural Bridge for Menstrual Cycle-Related Exercise Drop-Off

Samphire Neuroscience • International Society for Exercise Neuroscience • 18–19 July 2026

Multisession transcranial direct current stimulation and aerobic exercise synergistically improve food craving symptoms, impulsivity, and cognitive flexibility in women with overweight and obesity: a randomized controlled trial

Khataei, S. M. (et al) • 2025

PMDD, Mood & Mental Wellbeing

5 papers
Samphire research
Poster abstract

Interrupting the cycle: at-home neuromodulation as an upstream strategy for premenstrual low mood

Samphire Neuroscience • Menstruation Research Conference • 7–8 July 2026

Efficacy and safety of home-based transcranial direct current stimulation (tDCS) on patients with depressive disorders: a systematic review and meta-analysis of randomized clinical trials

Moshfeghinia, R. (et al) • 2025

Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids

Stiernam, L. (et al) • 2023

The association between premenstrual dysphoric disorder and depression: A systematic review

Eccles, H. (et al) • 2023

Premenstrual dysphoric disorder and changes in frontal alpha asymmetry

Baehr, E. (et al) • 2004

PMS & Dysmenorrhea

7 papers
Samphire research
Original manuscript

Home-based transcranial direct current stimulation for menstrual pain and premenstrual symptoms: a randomized controlled trial

da Silva, T. (et al) • International Journal of Women's Health • 1 May 2026

Samphire research
Protocol

Home-based self-administered transcranial direct current stimulation for women affected by primary dysmenorrhoea in Northeastern Brazil: a protocol study

da Silva, T. (et al) • BMJ Open • 13 July 2025

Samphire research
Original manuscript

Clinical usability study of a home-based self-administration transcranial direct current stimulation for primary dysmenorrhea: A randomized controlled trial

Rodrigues, Y. (et al) • PLOS One • 2 May 2024

Samphire research
Original manuscript

Modelling and Preliminary Clinical Validation of Home-based Menstrual Neuromodulation Therapy

Radyte, E. (et al) • IEEE Xplore • 17 December 2024

Samphire research
Abstract

Development and testing of a novel IoT consumer tDCS device for the treatment of primary dysmenorrhea

Radyte, E. (et al) • Brain Stimulation • 1 February 2023

Effects of Transcranial Direct Current Stimulation for Treatment of Primary Dysmenorrhea: Preliminary Results of a Randomized Sham-Controlled Trial

Pegado, R. et al • 2020

Modulating Anxiety and Functional Capacity with Anodal tDCS Over the Left Dorsolateral Prefrontal Cortex in Primary Dysmenorrhea

Dutra, L. (et al) • 2020

Safety & tDCS Mechanism

4 papers

Mechanisms of action of transcranial direct current stimulation

Yavari, F. (et al) • 2024

Safety of Transcranial Direct Current Stimulation in Neurorehabilitation

Ko, M. (et al) • 2021

Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation

Chase, H. (et al) • 2020

Safety of transcranial Direct Current Stimulation: Evidence Based Update 2016

Biksom, M. (et al) • 2016

Trial Design & Methodology

1 papers
Samphire research
Poster abstract

Cycle-timed design considerations for decentralised neuromodulation trials in women's health

Samphire Neuroscience • International Neuromodulation Society Annual Meeting • 11–14 May 2026

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